Histological examination

Histology is a major part of pathomorphological examination and a golden standard of diagnostics of oncological diseases. Only histological examination allows to fully identify biological features of the tumor, formulate a diagnosis, and correctly prescribe an adequate treatment. 

The object of study in this method is an area of a tissue with preserved inner structure obtained with core-needle biopsy (trephine-biopsy) or a surgically removed part of the tissue. Histological examination allows to distinguish a benign and a malignant process a lot more accurately and reliably than a cytological examination, as well as to identify the histological type of the neoplasm, determine the differentiation grade of a malignant tumor (G). Planned pathomorphological examination of a surgical specimen allows to estimate the actual size of the pathological lesion, assess the extent of the performed radical surgical intervention (how clean are the surgical margins of the excision) and the degree of response to neoadjuvant therapy (if such was performed), formulate a conclusion in accordance with all accepted requirements and international classification systems, particularly according to the TNM classification.  

Online reference